Trephina Gorge, in the East MacDonnell Ranges, is noted for its sheer quartzite cliffs and River Red Gum lined watercourses. It is one of two gorges that intersect the East MacDonnell Ranges. The other is John Hayes Rock Hole.
The area is significant to the Eastern Arrernte Aboriginal people and contains sites that are part of the Wallaby dreaming trail. Once a part of the Garden Station, the park has strong historic links with the early settlement of Central Australia.